Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida

被引：21

作者：

Erkel, G ^{[1
]}

Becker, U ^{[1
]}

Anke, T ^{[1
]}

STerner, O ^{[1
]}

机构：

[1] LUND UNIV,DIV ORGAN CHEM 2,S-22100 LUND,SWEDEN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 12期

关键词：

D O I：

10.7164/antibiotics.49.1189

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nidulal (1), a novel inducer of differentiation of human HL-60 promyelocytic leukemia cells, was isolated from fermentations of the basidiomycete Nidula candida together with low amounts of niduloic acid (2). Both compounds are bisabolane sesquiterpenes. Their structures were elucidated by spectroscopic methods. In reporter gene assays nidulal (1) preferentially activated the transcription factor complex AP-1-mediated expression of secreted alkaline phosphatase in COS-7 cells. In addition nidulal (1) and niduloic acid (2) exhibited weak cytotoxic and antibiotic activities.

引用

页码：1189 / 1195

页数：7

共 15 条

[1] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST [J].