Global sperm deoxyribonucleic acid methylation is unaffected in protamine-deficient infertile males

被引：32

作者：

Aoki, Vincent W.

Emery, Benjamin R.

Carrell, Douglas T.

机构：

[1] Univ Utah, Sch Med, Androl Lab, Salt Lake City, UT 84108 USA

[2] Univ Utah, Sch Med, IVF Lab, Salt Lake City, UT 84108 USA

[3] Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT 84108 USA

[4] Univ Utah, Sch Med, Dept Physiol, Salt Lake City, UT 84108 USA

[5] Univ Utah, Sch Med, Dept Obstet & Gynecol, Salt Lake City, UT 84108 USA

来源：

FERTILITY AND STERILITY | 2006年 / 86卷 / 05期

关键词：

D O I：

10.1016/j.fertnstert.2006.04.023

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Sperm protamine-1 (P1) and protamine-2 (P2) concentrations were evaluated concomitantly with global DNA methylation patterns in a population of male infertility patients. Protamine quantification and immunofluorescence microscopy in conjunction with quantitative image analysis revealed no significant relationships between the P1/P2 ratio, P1 concentrations, or P2 concentrations and levels of global DNA methylation in mature spermatozoa.

引用

页码：1541 / 1543

页数：3

共 24 条

[1] Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males [J].