In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" plants

被引：11

作者：

Pavan, Fernando R. ^{[1
]}

Sato, Daisy N. ^{[2
]}

Higuchi, Celio T. ^{[1
]}

Santos, Adolfo C. B. ^{[1
]}

Vilegas, Wagner ^{[3
]}

Leite, Clarice. Q. F. ^{[1
]}

机构：

[1] Univ Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil

[2] Adolfo Lutz Inst, Lab Micobacteriol, BR-14085410 Ribeirao Preto, SP, Brazil

[3] Univ Estadual Paulista, Dept Quim Organ, Inst Quim Araraquara, BR-14800900 Araraquara, SP, Brazil

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2009年 / 19卷 / 1B期

基金：

巴西圣保罗研究基金会;

关键词：

Brazilian "Cerrado" plants; Mycobacterium tuberculosis; antitubercular activity; MABA;

D O I：

10.1590/S0102-695X2009000200004

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The aim of this work was to carry out a screening of some plants of this Brazilian region with activity against Mycobacterium tuberculosis. Chloroform and methanol extracts of 37 plant species distributed among 17 families from Brazilian "Cerrado" which were tested against M tuberculosis H(37)Rv and the Minimum Inhibitory Concentration.(MIC) was determined by the use of Microplate Alamar Blue Assay (MABA). Crude extracts from sixteen plants showed MIC value of <= 125 mu g/mL and three 31.2 mu g/mL. These results suggest that the Brazilian "Cerrado" may be a source of plants that have activity anti-M tuberculosis constituents that can be extracted by polars and apolars solvents.

引用

页码：204 / 206

页数：3

共 11 条

[1]

Unusual naphthoquinones, catechin and triterpene from Byrsonima microphylla [J].

Aguiar, RM ;

David, JP ;

David, JM .

PHYTOCHEMISTRY, 2005, 66 (19) :2388-2392

[2]

ALMEIDA SP, 1998, PLANALTINA, P38

[3]

Antimycobacterial plant terpenoids [J].

Cantrell, CL ;

Franzblau, SG ;

Fischer, NH .

PLANTA MEDICA, 2001, 67 (08) :685-694

[4]

Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[5]

Antimycobacterial natural products [J].

Copp, BR .

NATURAL PRODUCT REPORTS, 2003, 20 (06) :535-557

[6]

Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay [J].

Franzblau, SG ;

Witzig, RS ;

McLaughlin, JC ;

Torres, P ;

Madico, G ;

Hernandez, A ;

Degnan, MT ;

Cook, MB ;

Quenzer, VK ;

Ferguson, RM ;

Gilman, RH .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (02) :362-366

[7]

Antitubercular constituents of Valeriana laxiflora [J].

Gu, JQ ;

Wang, YH ;

Franzblau, SG ;

Montenegro, G ;

Yang, DZ ;

Timmermann, BN .

PLANTA MEDICA, 2004, 70 (06) :509-514

[8]

TRITERPENES AND ANTITUBERCULAR ACTIVITY OF Byrsonima crassa [J].

Higuchi, Celio Takashi ;

Pavan, Fernando Rogerio ;

Fujimura Leite, Clarice Queico ;

Sannomiya, Miriam ;

Vilegas, Wagner ;

de Andrade Leite, Sergio Roberto ;

Sacramento, Luis Vitor S. ;

Sato, Daisy Nakamura .

QUIMICA NOVA, 2008, 31 (07) :1719-1721

[9]

MENDONCA RC, 1998, PLANALTINA, P286

[10]

Antimycobacterial screening of some Turkish plants [J].

Tosun, F ;

Kizilay, ÇA ;

Sener, B ;

Vural, M ;

Palittapongarnpim, P .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 95 (2-3) :273-275

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