Noncanonical Wnt signaling and neural polarity

被引：140

作者：

Montcouquiol, Mireille

Crenshaw, E. Bryan, III

Kelley, Matthew W.

机构：

[1] Childrens Hosp Philadelphia, Mammalian Neurogenet Grp, Ctr Childhood Commun, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA

[3] NIDCD, Sect Dev Neurosci, NIH, Bethesda, MD 20982 USA

来源：

ANNUAL REVIEW OF NEUROSCIENCE | 2006年 / 29卷

关键词：

convergent extension; neurulation; gastrulation; planar cell polarity; inner car; migration; mechanosensory hair cell;

D O I：

10.1146/annurev.neuro.29.051605.112933

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Wnt signaling pathway regulates multiple events in development and disease in both vertebrates and invertebrates. Recently, the noncanonical Wnt signaling cascades, those that do not signal through beta-catenin, have gained prominence for their role in the regulation of cellular polarity It is not surprising that cellular polarization influences a number of different developmental events within the nervous system, including neurulation and neural tube closure, cellular migration, and uniform orientation of cells within an epithelial plane (planar cell polarity). In this review, we describe the differences between the canonical and noncanonical pathways, summarize recent data illustrating the roles of the noncanonical Wnt pathway in different polarizing events during neural development, and discuss the potential molecular mechanisms that underlie the generation of cellular asymmetry and polarity.

引用

页码：363 / 386

页数：24

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