Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

被引：80

作者：

Cohen, Alan A. ^{[1
]}

Kennedy, Brian K. ^{[2
,3
,4
,5
]}

Anglas, Ulrich ^{[6
,7
,8
]}

Bronikowski, Anne M. ^{[9
]}

Deelen, Joris ^{[10
,11
]}

Dufour, Frederik ^{[1
]}

Ferbeyre, Gerardo ^{[12
]}

Ferrucci, Luigi ^{[13
]}

Franceschi, Claudio ^{[14
,15
,16
]}

Frasca, Daniela ^{[17
]}

Friguet, Bertrand ^{[18
]}

Gaudreau, Pierrette ^{[12
,19
]}

Gladyshev, Vadim N. ^{[20
,21
]}

Gonos, Efstathios S. ^{[22
]}

Gorbunova, Vera ^{[23
]}

Gut, Philipp ^{[24
]}

Ivanchenko, Mikhail ^{[25
]}

Legault, Veronique ^{[1
]}

Lemaitre, Jean-Francois ^{[26
]}

Liontis, Thomas ^{[6
,7
,8
]}

Liu, Guang-Hui ^{[27
]}

Liu, Mingxin ^{[1
]}

Maier, Andrea B. ^{[28
,29
]}

Nobrega, Otavio T. ^{[30
,31
]}

Rikkert, Marcel G. M. Olde ^{[32
]}

Pawelec, Graham ^{[33
,34
]}

Rheault, Sylvie ^{[35
,36
]}

Senior, Alistair M. ^{[37
,38
]}

Simm, Andreas ^{[39
]}

Soo, Sonja ^{[6
,7
,8
]}

Traa, Annika ^{[6
,7
,8
]}

Ukraintseva, Svetlana ^{[40
]}

Vanhaelen, Quentin ^{[41
]}

Van Raamsdonk, Jeremy M. ^{[6
,42
,43
]}

Witkowski, Jacek M. ^{[44
]}

Yashin, Anatoliy, I ^{[40
]}

Ziman, Robert ^{[1
]}

Fulop, Tamas ^{[45
,46
]}

机构：

[1] Univ Sherbrooke, Dept Family Med, Grp Rech PRIMUS, 3001 12e Ave N, Sherbrooke, PQ J1H 5N4, Canada

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, MD 7,8 Med Dr, Singapore 117596, Singapore

[3] Natl Univ Hlth Syst NUHS, Ctr Hlth Longev, 1E Kent Ridge Rd, Singapore 119228, Singapore

[4] ASTAR, Singapore Inst Clin Sci, Brenner Ctr Mol Med, 30 Med Dr, Singapore 117609, Singapore

[5] Buck Inst Res Ageing, 8001 Redwood Blvd, Novato, CA 94945 USA

[6] McGill Univ, Dept Neurol & Neurosurg, 3801 Univ St, Montreal, PQ H3A 2B4, Canada

[7] McGill Univ Hlth Ctr, Metab Disorders & Complicat Program, Res Inst, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada

[8] McGill Univ Hlth Ctr, Res Inst, Brain Repair & Integrat Neurosci Program, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada

[9] Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA 50011 USA

[10] Max Planck Inst Biol Ageing, POB 41 06 23, D-50866 Cologne, Germany

[11] Leiden Univ Med Ctr, Dept Biomed Data Sci, Mol Epidemiol, POB 9600, NL-2300 RC Leiden, Netherlands

[12] Ctr Hosp Univ Montreal CRCHUM, Ctr Rech, 900 St Denis St, Montreal, PQ H2X 0A9, Canada

[13] NIA, Translat Gerontol Branch, Longitudinal Studies Sect, NIH,MedStar Harbor Hosp, 3001 S Hanover St, Baltimore, MD 21225 USA

[14] Univ Bologna, Dept Expt Diagnost & Specialty Med, Alma Mater Studiorum, 33 Via Zamboni, I-40126 Bologna, BO, Italy

[15] IRCCS, Ist Sci Neurol Bologna, Padigl G,3 Via Altura, I-40139 Bologna, BO, Italy

[16] Lobachevsky State Univ Nizhny Novgorod Natl Res U, Inst Informat Technol Math & Mech TIMM, Dept Appl Math, 23 Gagarin Ave, Nizhnii Novgorod 603950, Russia

[17] Univ Miami, Dept Microbiol & Immunol, Miller Sch Med, 1600 NW 10th Ave, Miami, FL 33136 USA

[18] Sorbonne Univ, CNRS, INSERM, Inst Biol Paris Seine,Biol Adaptat & Aging, B2A IBPS, F-75005 Paris, France

[19] Univ Montreal, Dept Med, 2900 Boul Edouard Montpetit, Montreal, PQ H3T 1J4, Canada

[20] Brigham & Womens Hosp, Dept Med, Div Genet, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[21] Harvard Med Sch, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[22] Natl Hellen Res Fdn, Inst Chem Biol, 48 Vassileos Constantinou Ave, Athens 11635, Greece

[23] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

[24] Nestle Res, Nestle Inst Hlth Sci, EPFL Innovat Pk, CH-1015 Lausanne, Switzerland

[25] Lobachevsky State Univ Nizhny Novgorod, Dept Appl Math, Nizhnii Novgorod 603950, Russia

[26] Univ Lyon 1, Univ Lyon, Lab Biometrie & Biol Evolut UMR5558, CNRS, F-69622 Villeurbanne, France

[27] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, 1 Beichen West Rd, Beijing 100101, Peoples R China

[28] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, AgeMelbourne, 34-54 Poplar Rd, Parkville, Vic 3052, Australia

[29] Vrije Univ, Fac Behav & Movement Sci, Dept Human Movement Sci, Amsterdam Movement Sci,AgeAmsterdam, Van der Boechorastr 7, NL-1081 BT Amsterdam, Netherlands

[30] Univ Brasilia UnB, Univ Hosp, Med Ctr Elderly, BR-70910900 Brasilia, DF, Brazil

[31] Inst Univ Geriatrie Montreal CRIUGM, Ctr Rech, 4545 Chemin Queen Mary, Montreal, PQ H3W 1W5, Canada

[32] Radboud Univ Nijmegen, Dept Geriatr, Med Ctr, Reinier Postlaan 4, NL-6525 GC Nijmegen, Netherlands

[33] Univ Tubingen, Dept Immunol, Morgenstelle 15, D-72076 Tubingen, Germany

[34] Hlth Sci North Res Inst, 56 Walford Rd, Sudbury, ON P3E 2H2, Canada

[35] Univ Montreal, Dept Neurosci, 2960 Chemin Tour, Montreal, PQ H3T 1J4, Canada

[36] Inst Univ Geriatrie Montreal, Ctr Rech, 4545 Chemin Queen Mary, Montreal, PQ H3W 1W4, Canada

[37] Univ Sydney, Charles Perkins Ctr, Camperdown, NSW 2006, Australia

[38] Univ Sydney, Sch Life & Environm Sci, Camperdown, NSW 2006, Australia

[39] Univ Hosp Halle Saale, Univ Clin & Outpatient Clin Cardiac Surg, Middle German Heart Ctr, Ernst Grube Str 40, D-06120 Saa Halle, Saale, Germany

[40] Duke Univ, Social Sci Res Inst, Biodemog Aging Res Unit, 2024W Main St, Durham, NC 27705 USA

[41] Insilico Med Hong Kong Ltd, Pak Shek Kok, 307A,Core Bldg 1,1 Sci Pk East Ave, Hong Kong, Peoples R China

[42] McGill Univ, Dept Med, Div Expt Med, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada

[43] Harvard Med Sch, Dept Genet, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[44] Med Univ Gdansk, Dept Pathophysiol, M Sklodowskiej Curie 3a St, PL-80210 Gdansk, Poland

[45] Univ Sherbrooke, Dept Med, Geriatr Div, 3001 12 Ave N, Sherbrooke, PQ J1H 5N4, Canada

[46] Res Ctr Aging, 1036 Rue Belvedere S, Sherbrooke, PQ J1H 4C4, Canada

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2020年 / 191卷

基金：

美国国家卫生研究院; 加拿大健康研究院; 澳大利亚研究理事会;

关键词：

Aged; Aging; Aging paradigm; Biology of aging; Aging mechanisms; Aging interventions; Epidemiology of aging; Evolution of aging; Philosophy of science;

D O I：

10.1016/j.mad.2020.111316

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accordingly, we undertook a systematic survey of our 71 participants on key questions that were raised during the debate and symposium, eliciting 37 responses. The results confirmed the impression from the symposium: there is marked disagreement on the most fundamental questions in the field, and little consensus on anything other than the heterogeneous nature of aging processes. Areas of major disagreement included what participants viewed as the essence of aging, when it begins, whether aging is programmed or not, whether we currently have a good understanding of aging mechanisms, whether aging is or will be quantifiable, whether aging will be treatable, and whether many non-aging species exist. These disagreements lay bare the urgent need for a more unified and cross-disciplinary paradigm in the biology of aging that will clarify both areas of agreement and disagreement, allowing research to proceed more efficiently. We suggest directions to encourage the emergence of such a paradigm.

引用

页数：8

共 27 条

[21]

Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age? [J].