Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing

被引：90

作者：

Roza, C

Puel, JL

Kress, M

Baron, A

Diochot, S

Lazdunski, M

Waldmann, R

机构：

[1] Univ Erlangen Nurnberg, Dept Physiol & Expt Pathophysiol, D-91054 Erlangen, Germany

[2] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 6097, F-06560 Valbonne, France

[3] Dept Physiol, A-6020 Innsbruck, Austria

[4] INSERM, U583, F-34090 Montpellier, France

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2004年 / 558卷 / 02期

关键词：

D O I：

10.1113/jphysiol.2004.066001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mechanosensitive cation channels are thought to be crucial for different aspects of mechano-perception, such as hearing and touch sensation. In the nematode C elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechano-sensitive cation channels. Mammalian degenerin homologues, the H+-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.

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页码：659 / 669

页数：11

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