Synthesis of the fully functionalized tris-oxazole fragment found in metabolites derived from marine organisms

被引：32

作者：

Liu, P ^{[1
]}

Celatka, CA ^{[1
]}

Panek, JS ^{[1
]}

机构：

[1] BOSTON UNIV,METCALF CTR SCI & ENGN,DEPT CHEM,BOSTON,MA 02215

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 31期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)01218-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the fully functionalized tris-oxazole fragment 9 found in marine metabolites kabiramide C and halichondramide is reported employing modified Hantzsch methodology. Starting with the condensation reaction between cinnamamide 1 and ethyl bromopyruvate 2, the synthetic sequence leading to 9 was carried out in 13 steps with an overall yield of 26%. (C) 1997 Elsevier Science Ltd.

引用

页码：5445 / 5448

页数：4