Synthesis of new dehydro 2-azatryptophans and derivatives via Heck cross-coupling reactions of 3-iodoindazoles with methyl 2-(acetylamino)acrylate

被引：29

作者：

Crestey, Francois ^{[1
]}

Collot, Valerie ^{[1
]}

Stiebing, Silvia ^{[1
]}

Rault, Sylvain ^{[1
]}

机构：

[1] Univ Caen, CERMN, UPRES, EA3915,UFR Sci Pharmaceut, F-14032 Caen, France

来源：

SYNTHESIS-STUTTGART | 2006年 / 20卷 / 20期

关键词：

dehydro; 2-azatryptophans; protective amino acid derivatives; catalytic hydrogenation; Heck cross-coupling reaction; 3-iodoindazoles; 2-(acetylamino)acrylate;

D O I：

10.1055/s-2006-950242

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes the Heck cross-coupling reaction of 3-iodoindazoles with methyl 2-(acetylamino)acrylate as a general route to new dehydro 2-azatryptophans and protected amino acid derivatives after catalytic hydrogenation.

引用

页码：3506 / 3514

页数：9

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