Drugs targeting the renin-angiotensin-aldosterone system

被引：350

作者：

Zaman, MA ^{[1
]}

Oparil, S ^{[1
]}

Calhoun, DA ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Vasc Biol & Hypertens Program, Div Cardiovasc Dis, Dept Med, Birmingham, AL 35294 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 08期

关键词：

D O I：

10.1038/nrd873

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Effective antihypertensive therapy has made a major contribution to the reductions in the morbidity and mortality of cardiovascular disease that have been achieved since the 1960s. However, blood-pressure control with conventional drugs has not succeeded in reducing cardiovascular disease risks to levels seen in normotensive persons. Drugs that inhibit or antagonize components of the renin-angiotensin-aldosterone system are addressing this deficiency by targeting both blood pressure and related structural and functional abnormalities of the heart and blood vessels, thus preventing target-organ damage and related cardiovascular events.

引用

页码：621 / 636

页数：16

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