miRNAs in PAH: biomarker, therapeutic target or both?

被引：35

作者：

Meloche, Jolyane ^{[1
]}

Pflieger, Aude ^{[1
]}

Vaillancourt, Mylene ^{[1
]}

Graydon, Colin ^{[1
]}

Provencher, Steeve ^{[1
]}

Bonnet, Sebastien ^{[1
]}

机构：

[1] Univ Laval, Dept Med, Pulm Hypertens Grp, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ G1V 4G5, Canada

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 08期

基金：

加拿大健康研究院;

关键词：

PULMONARY ARTERIAL-HYPERTENSION; 6-MINUTE WALK DISTANCE; MOUSE MODELS; MICRORNA; 210; LUNG; DYSREGULATION; MIR-17-92; CELLS; RNA;

D O I：

10.1016/j.drudis.2014.05.015

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Pulmonary arterial hypertension (PAH) is characterized by progressive increase in pulmonary vascular resistance leading to right ventricular hypertrophy and failure. There is a need to find new biomarkers to detect PAH at its early stages and also for new, more effective treatments for this disease. miRNAs have emerged as key players in cardiovascular diseases and cancer development and progression and, more recently, in PAH pathogenesis. In this review, we focus on the potential of miRNAs as biomarkers and new therapeutic targets for PAH.

引用

收藏

页码：1264 / 1269

页数：6

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