5-HT2C receptor activation decreases appetite and body weight in obese subjects

被引：140

作者：

Sargent, PA ^{[1
]}

Sharpley, AL ^{[1
]}

Williams, C ^{[1
]}

Goodall, EM ^{[1
]}

Cowen, PJ ^{[1
]}

机构：

[1] UNIV OXFORD, LITTLEMORE HOSP, DEPT PSYCHIAT, OXFORD OX4 4XN, ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1997年 / 133卷 / 03期

基金：

英国医学研究理事会;

关键词：

mCPP; 5-HT receptor; body weight; obesity;

D O I：

10.1007/s002130050407

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of 2 weeks administration of the 5-HT2C receptor agonist, m-chlorophenylpiperazine (mCPP), on appetite and body weight in 18 moderately obese subjects in a double-blind, placebo-controlled trial. mCPP caused a small but significant (0.75 kg) reduction in body weight and in subjective ratings of hunger, Plasma prolactin was significantly elevated by the final dose of mCPP. Our data suggest that during 2 weeks treatment in humans, mCPP may continue to activate brain 5-HT2C receptors, and that this effect is associated with decreases in appetite and body weight.

引用

页码：309 / 312

页数：4

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