Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

被引：245

作者：

Lawrie, AM

Noble, MEM

Tunnah, P

Brown, NR

Johnson, LN

Endicott, JA

机构：

[1] UNIV OXFORD, MOL BIOPHYS LAB, OXFORD OX1 3QU, ENGLAND

[2] OXFORD CTR MOL SCI, OXFORD OX1 3QU, ENGLAND

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 10期

关键词：

D O I：

10.1038/nsb1097-796

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 strauroporine complex explains the tight binding of this inhibitor and suggests features to be exploited in the design of specific inhibitors of CDKs.

引用

页码：796 / 801

页数：6

共 41 条

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