ABSOLUTE-CONFIGURATION OF STAUROSPORINE BY X-RAY-ANALYSIS

被引：92

作者：

FUNATO, N

TAKAYANAGI, H

KONDA, Y

TODA, Y

HARIGAYA, Y

IWAI, Y

OMURA, S

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO INST,MINATO KU,TOKYO 108,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 08期

关键词：

D O I：

10.1016/0040-4039(94)88036-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereostructure of staurosporine (1) was determined absolutely to be 2'S, 3'R, 4'R, 6R-configurations by means of X-ray crystallographic analysis of 4'-N-methylstaurosporine methiodide (2).

引用

页码：1251 / 1254

页数：4

共 17 条

[1] BRODSKY BC, 1991, INT S BIOL ACT, P2
[2] THE DESIGN OF INHIBITORS OF PROTEIN-KINASE-C - THE SOLUTION CONFORMATION OF STAUROSPORINE
DAVIS, PD
HILL, CH
THOMAS, WA
WHITCOMBE, IWA
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (03) : 182 - 184
[3] X-RAY CRYSTAL-STRUCTURE OF STAUROSPORINE - NEW ALKALOID FROM A STREPTOMYCES STRAIN
FURUSAKI, A
HASHIBA, N
MATSUMOTO, T
HIRANO, A
IWAI, Y
OMURA, S
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (18) : 800 - 801
[4] THE CRYSTAL AND MOLECULAR-STRUCTURE OF STAUROSPORINE, A NEW ALKALOID FROM A STREPTOMYCES STRAIN
FURUSAKI, A
HASHIBA, N
MATSUMOTO, T
HIRANO, A
IWAI, Y
OMURA, S
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1982, 55 (12) : 3681 - 3685
[5] A STEREOSELECTIVE SYNTHESIS OF INDOLE-BETA-N-GLYCOSIDES - AN APPLICATION TO THE SYNTHESIS OF REBECCAMYCIN
GALLANT, M
LINK, JT
DANISHEFSKY, SJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (02) : 343 - 349
[6] 11-HYDROXYSTAUROSPORINE - A HIGHLY CYTOTOXIC, POWERFUL PROTEIN-KINASE-C INHIBITOR FROM A TUNICATE
KINNEL, RB
SCHEUER, PJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (23) : 6327 - 6329
[7] A NEW INHIBITOR OF PROTEIN-KINASE-C, RK-1409B (4'-DEMETHYLAMINO-4'-HYDROXY-3'-EPISTAUROSPORINE)
KOSHINO, H
OSADA, H
AMANO, S
ONOSE, R
ISONO, K
[J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (09) : 1428 - 1432
[8] KOSHINO H, 1990, J ANTIBIOT, V45, P195
[9] BIOSYNTHESIS OF STAUROSPORINE .1. H-1-NMR AND C-13-NMR ASSIGNMENTS
MEKSURIYEN, D
CORDELL, GA
[J]. JOURNAL OF NATURAL PRODUCTS, 1988, 51 (05): : 884 - 892
[10] SYNTHESIS OF THE STAUROSPORINE AGLYCON
MOODY, CJ
RAHIMTOOLA, KF
PORTER, B
ROSS, BC
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (07) : 2105 - 2114

← 1 2 →