Directed evolution as a method to create enantioselective cyclohexanone monooxygenases for catalysis in Baeyer-Villiger reactions

被引：126

作者：

Reetz, MT

Brunner, B

Schneider, T

Schulz, F

Clouthier, CM

Kayser, MM

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

[2] Univ New Brunswick, Dept Phys Sci, St John, NB E2L 4L5, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 31期

关键词：

asymmetric catalysis; Baeyer-Villiger reactions; directed evolution; enzyme catalysis; protein engineering;

D O I：

10.1002/anie.200460272

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direction and degree of enantioselectivity in the cyclohexanone monooxygenase catalyzed air-mediated Baeyer-Villiger reactions, such as the desymmetrization of 1, can be controlled by directed evolution.

引用

页码：4075 / 4078

页数：4

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