Protection of Bcl-2 by salubrinal

被引：30

作者：

Kessel, David ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Dept Med, Detroit, MI 48201 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 346卷 / 04期

关键词：

apoptosis; autophagy; Bcl-2; photodynamic; salubrinal; PHOTODAMAGE; APOPTOSIS;

D O I：

10.1016/j.bbrc.2006.06.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The drug salubrinal has been identified as an inhibitor of phosphatases that act on the eukaryotic translation initiation factor 2 subunit (6IF2 alpha). The resulting maintenance of protein phosphorylation results in enhanced protection from the adverse effects of initiators of the unfolded protein response. We found that salubrinal can also interact with the anti-apoptotic protein Bcl-2, inhibiting binding of the non-peptidic antagonist HA14-1 and of a porphycene that can catalyze Bcl-2 photodamage. As a result, salubrinal offers protection from the apoptotic and autophagic effects that can result from loss of Bcl-2 function. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1320 / 1323

页数：4

共 17 条

[1] A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
Boyce, M
Bryant, KF
Jousse, C
Long, K
Harding, HP
Scheuner, D
Kaufman, RJ
Ma, DW
Coen, DM
Ron, D
Yuan, JY
[J]. SCIENCE, 2005, 307 (5711) : 935 - 939
[2] Design and synthesis of rhodamine 110 derivative and caspase-3 substrate for enzyme and cell-based fluorescent assay
Cai, SX
Zhang, HZ
Guastella, J
Drewe, J
Yang, W
Weber, E
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (01) : 39 - 42
[3] A mechanism for the proapoptotic activity of ursodeoxycholic acid: effects on Bcl-2 conformation
Castelli, M
Reiners, JJ
Kessel, D
[J]. CELL DEATH AND DIFFERENTIATION, 2004, 11 (08) : 906 - 914
[4] Ruthenium red-mediated suppression of Bcl-2 loss and Ca2+release initiated by photodamage to the endoplasmic reticulum:: scavenging of reactive oxygen species
Kessel, D
Castelli, M
Reiners, JJ
[J]. CELL DEATH AND DIFFERENTIATION, 2005, 12 (05) : 502 - 511
[5] Kessel D, 2002, PHOTOCHEM PHOTOBIOL, V76, P314, DOI 10.1562/0031-8655(2002)076<0314:ARTPTV>2.0.CO
[6] 2
[7] Kessel D, 2001, PHOTOCHEM PHOTOBIOL, V74, P318, DOI 10.1562/0031-8655(2001)074<0318:ETBITT>2.0.CO
[8] 2
[9] Development by self-digestion: Molecular mechanisms and biological functions of autophagy
Levine, B
Klionsky, DJ
[J]. DEVELOPMENTAL CELL, 2004, 6 (04) : 463 - 477
[10] Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
Lu, PD
Jousse, C
Marciniak, SJ
Zhang, YH
Novoa, I
Scheuner, D
Kaufman, RJ
Ron, D
Harding, HP
[J]. EMBO JOURNAL, 2004, 23 (01) : 169 - 179

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