ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

被引：347

作者：

Hogan, Benjamin M. ^{[1
,2
]}

Bos, Frank L. ^{[1
,2
,3
]}

Bussmann, Jeroen ^{[1
,2
]}

Witte, Merlijn ^{[1
,2
]}

Chi, Neil C. ^{[4
,5
,6
,7
,8
]}

Duckers, Henricus J. ^{[3
]}

Schulte-Merker, Stefan ^{[1
,2
]}

机构：

[1] KNAW, Hubrecht Inst, Utrecht, Netherlands

[2] Univ Med Ctr, Utrecht, Netherlands

[3] Erasmus Univ, Med Ctr, Thoraxctr, Rotterdam, Netherlands

[4] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Program Dev Biol, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Genet Program, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Program Human Genet, San Francisco, CA 94143 USA

[8] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 04期

关键词：

ENDOTHELIAL-GROWTH-FACTOR; LYMPHATIC-SYSTEM; ZEBRAFISH; RECEPTOR; PROX1; MICE;

D O I：

10.1038/ng.321

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

引用

页码：396 / 398

页数：3

共 14 条

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