The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases

被引：89

作者：

Acker, Till

Fandrey, Joachim

Acker, Helmut

机构：

[1] Univ Duisburg Essen, Inst Physiol, D-45147 Essen, Germany

[2] Univ Frankfurt Klinikum, Neurol Inst, Edinger Inst, D-60528 Frankfurt, Germany

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 71卷 / 02期

关键词：

ROS; HIF; PHD; cytochromes; ion channels; oxygen-sensing;

D O I：

10.1016/j.cardiores.2006.04.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxylases (PHDs) and HIF asparagyl hydroxylase FIH-1 (factor-inhibiting HIF). Different oxygen sensitivities, cell-specific distribution and subcellular localization of specific oxygen-sensing cascades involving reactive oxygen species (ROS) as second messengers may help to tailor various adaptive responses according to differences in tissue oxygen availability. Herein, we propose an integrated model for these various oxygen-sensing mechanisms that very efficiently regulate HIF-alpha activity and plasma membrane potassium-channel (PMPC) conductivity. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.

引用

页码：195 / 207

页数：13

共 114 条

[1] The oxygen sensing signal cascade under the influence of reactive oxygen species
Acker, H
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1464) : 2201 - 2210
[2] Genetic evidence for a tumor suppressor role of HIF-2α
Acker, T
Diez-Juan, A
Aragones, J
Tjwa, M
Brusselmans, K
Moons, L
Fukumura, D
Moreno-Murciano, MP
Herbert, JM
Burger, A
Riedel, J
Elverl, G
Flamme, I
Maxwell, PH
Collen, D
Dewerchin, M
Jain, RK
Plate, KH
Carmeliet, P
[J]. CANCER CELL, 2005, 8 (02) : 131 - 141
[3] Cellular oxygen sensing need in CNS function: physiological and pathological implications
Acker, T
Acker, H
[J]. JOURNAL OF EXPERIMENTAL BIOLOGY, 2004, 207 (18) : 3171 - 3188
[4] Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
Appelhoff, RJ
Tian, YM
Raval, RR
Turley, H
Harris, AL
Pugh, CW
Ratcliffe, PJ
Gleadle, JM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (37) : 38458 - 38465
[5] Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors
Aprelikova, O
Chandramouli, GVR
Wood, M
Vasselli, JR
Riss, J
Maranchie, JK
Linehan, WM
Barrett, JC
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 92 (03) : 491 - 501
[6] O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase
Archer, SL
Reeve, HL
Michelakis, E
Puttagunta, L
Waite, R
Nelson, DP
Dinauer, MC
Weir, EK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) : 7944 - 7949
[7] Lack of oxygen sensing by mitochondria in platelets
Arthur, PG
Ngo, CT
Moretta, P
Guppy, M
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 266 (01): : 215 - 219
[8] Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect
Astrom, K
Cohen, JE
Willett-Brozick, JE
Aston, CE
Baysal, BE
[J]. HUMAN GENETICS, 2003, 113 (03) : 228 - 237
[9] Role of mitochondria in the regulation of hypoxia-inducible factor-1α in the rat carotid body glomus cells
Baby, SM
Roy, A
Lahiri, S
[J]. HISTOCHEMISTRY AND CELL BIOLOGY, 2005, 124 (01) : 69 - 76
[10] OS-9 interacts with hypoxia-inducible factor 1α and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1α
Baek, JH
Mahon, PC
Oh, J
Kelly, B
Krishnamachary, B
Pearson, M
Chan, DA
Giaccia, AJ
Semenza, GL
[J]. MOLECULAR CELL, 2005, 17 (04) : 503 - 512

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