The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases

被引：89

作者：

Acker, Till

Fandrey, Joachim

Acker, Helmut

机构：

[1] Univ Duisburg Essen, Inst Physiol, D-45147 Essen, Germany

[2] Univ Frankfurt Klinikum, Neurol Inst, Edinger Inst, D-60528 Frankfurt, Germany

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 71卷 / 02期

关键词：

ROS; HIF; PHD; cytochromes; ion channels; oxygen-sensing;

D O I：

10.1016/j.cardiores.2006.04.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxylases (PHDs) and HIF asparagyl hydroxylase FIH-1 (factor-inhibiting HIF). Different oxygen sensitivities, cell-specific distribution and subcellular localization of specific oxygen-sensing cascades involving reactive oxygen species (ROS) as second messengers may help to tailor various adaptive responses according to differences in tissue oxygen availability. Herein, we propose an integrated model for these various oxygen-sensing mechanisms that very efficiently regulate HIF-alpha activity and plasma membrane potassium-channel (PMPC) conductivity. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.

引用

页码：195 / 207

页数：13

共 114 条

[91] Richard DE, 2000, J BIOL CHEM, V275, P26765
[92] Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca2+]i and respiratory responses to hypoxia
Roy, A
Rozanov, C
Mokashi, A
Daudu, P
Al-mehdi, AB
Shams, H
Lahiri, S
[J]. BRAIN RESEARCH, 2000, 872 (1-2) : 188 - 193
[93] Effects of iron-chelators on ion-channels and HIF-1α in the carotid body
Roy, A
Li, JQ
Baby, SM
Mokashi, A
Buerk, DG
Lahiri, S
[J]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2004, 141 (02) : 115 - 123
[94] Role of components of the phagocytic NADPH oxidase in oxygen sensing
Sanders, KA
Sundar, KM
He, L
Dinger, B
Fidone, S
Hoidal, JR
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 2002, 93 (04) : 1357 - 1364
[95] Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Selak, MA
Armour, SM
MacKenzie, ED
Boulahbel, H
Watson, DG
Mansfield, KD
Pan, Y
Simon, MC
Thompson, CB
Gottlieb, E
[J]. CANCER CELL, 2005, 7 (01) : 77 - 85
[96] Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway
Srinivas, V
Leshchinsky, I
Sang, N
King, MP
Minchenko, A
Caro, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) : 21995 - 21998
[97] Topology of superoxide production from different sites in the mitochondrial electron transport chain
St-Pierre, J
Buckingham, JA
Roebuck, SJ
Brand, MD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) : 44784 - 44790
[98] Unusual cytochrome a592 with low PO2 affinity correlates as putative oxygen sensor with rat carotid body chemoreceptor discharge
Streller, T
Huckstorf, C
Pfeiffer, C
Acker, H
[J]. FASEB JOURNAL, 2002, 16 (08) : 1277 - +
[99] Tabata M, 2001, J CELL PHYSIOL, V186, P260, DOI 10.1002/1097-4652(200002)186:2<260::AID-JCP1025>3.0.CO
[100] 2-K

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