Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: A new approach toward prodrug-procontrast complexes

被引：28

作者：

Frullano, Luca ^{[1
]}

Tejerina, Baudilio ^{[1
]}

Meade, Thomas J. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem Biochem & Mol & Cell Biol, Evanston, IL 60208 USA

来源：

INORGANIC CHEMISTRY | 2006年 / 45卷 / 21期

关键词：

D O I：

10.1021/ic0612045

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.

引用

页码：8489 / 8491

页数：3

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