Investigations into a biomimetic approach toward CP-225,917 and CP-263,114

被引：56

作者：

Sulikowski, GA ^{[1
]}

Agnelli, F ^{[1
]}

Corbett, RM ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 02期

关键词：

D O I：

10.1021/jo9911286

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A biosynthesis of the structurally complex nonadride CP-225,917 (1) is outlined. A key step in this proposal is the dimerization of a C-16 anhydride derived from the condensation of lauric acid and oxaloacetic acid. An important element of this step is a templating effect imposed by two thioester linkages, reminiscent of a polyketide or fatty acid synthase pathway. On the basis of this principle, the dimerization of two C-11 anhydrides, templated by a 1,n-diol tether, leading to the core structure of CP-225,917 and CP-263,114 was investigated.

引用

页码：337 / 342

页数：6

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