Stereoselective synthesis of all stereoisomeric 2-amino-3-hydroxy-4-phenylbutanolides

被引：14

作者：

Gair, S

Jackson, RFW

Brown, PA

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHEM,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[2] ROCHE PROD LTD,RES CTR,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)00544-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselective methylation of the ketone 5a leads to the anti-derivative 4a; the other diastereoisomer 4b may be obtained by a deprotonation/reprotonation sequence. Each of the methylated products may be reduced stereoselectively in either sense by appropriate choice of reagent, providing a route to all stereoisomers of the title 2-amino-3-hydroxy-4-phenylbutanolides 10a-d. (C) 1997 Elsevier Science Ltd.

引用

页码：3059 / 3062

页数：4

共 13 条

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