Scaffolds for engineering novel binding sites in proteins

被引：129

作者：

Nygren, PA

Uhlen, M

机构：

[1] Dept. of Biochem. and Biotechnology, Roy. Inst. Technol. (KTH), T., Stockholm

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(97)80108-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The combination of combinatorial protein chemistry and powerful selection techniques has resulted in the development of novel protein ligands based on the randomization of surface residues of a parental protein which is used as a scaffold. Such binding proteins, selected from libraries via specific binding towards a given target ligand, have the potential to replace natural antibodies in various biotechnological applications.

引用

页码：463 / 469

页数：7

共 42 条

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