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Scaffolds for engineering novel binding sites in proteins

被引：129
作者：
Nygren, PA
Uhlen, M
机构：
[1] Dept. of Biochem. and Biotechnology, Roy. Inst. Technol. (KTH), T., Stockholm
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期
关键词：
D O I：
10.1016/S0959-440X(97)80108-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The combination of combinatorial protein chemistry and powerful selection techniques has resulted in the development of novel protein ligands based on the randomization of surface residues of a parental protein which is used as a scaffold. Such binding proteins, selected from libraries via specific binding towards a given target ligand, have the potential to replace natural antibodies in various biotechnological applications.
引用
收藏
页码：463 / 469
页数：7
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