Fabrication and characterization of electrospun cellulose/nano-hydroxyapatite nanofibers for bone tissue engineering

被引：121

作者：

Ao, Chenghong ^{[1
]}

Niu, Yan ^{[1
]}

Zhang, Ximu ^{[2
]}

He, Xu ^{[1
]}

Zhang, Wei ^{[1
]}

Lu, Canhui ^{[1
]}

机构：

[1] Sichuan Univ, Polymer Res Inst, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2017年 / 97卷

基金：

中国国家自然科学基金;

关键词：

Cotton cellulose; Electrospinning; Bone tissue engineering; NANO-HYDROXYAPATITE; NANOCOMPOSITES; SCAFFOLD; NANOPARTICLES; COMPOSITES;

D O I：

10.1016/j.ijbiomac.2016.12.091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nanofibrous scaffolds from cotton cellulose and nano-hydroxyapatite (nano-HA) were electrospun for bone tissue engineering. The solution properties of cellulose/nano-HA spinning dopes and their associated electrospinnability were characterized. Morphological, thermal and mechanical properties of the electrospun cellulose/nano-HA nanocomposite nanofibers (ECHNN) were measured and the biocompatibility of ECHNN with human dental follicle cells (HDFCs) was evaluated. Scanning electron microscope (SEM) images indicated that the average diameter of ECHNN increased with a higher nano-HA loading and the fiber diameter distributions were well within the range of natural ECM (extra cellular matrix) fibers (50-500nm). The ECHNN exhibited extraordinary mechanical properties with a tensile strength and a Young's modulus up to 70.6 MPa and 3.12 GPa respectively. Moreover, it was discovered that the thermostability of the ECHNN could be enhanced with the incorporation of nano-HA. Cell culture experiments demonstrated that the ECHNN scaffolds were quite biocompatible for HDFCs attachment and proliferation, suggesting their great potentials as scaffold materials in bone tissue engineering. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：568 / 573

页数：6

共 33 条

[1]

Cellulose in lithium chloride/N,N-dimethylacetamide, optimisation of a dissolution method using paper substrates and stability of the solutions [J].