Role of T cell costimulation in anti-viral immunity

被引：82

作者：

Bertram, EM

Dawicki, W

Watts, TH

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

[2] Australian Natl Univ, John Curtin Sch Med Res, Australian Phenom Facil, Canberra, ACT 2601, Australia

[3] Australian Natl Univ, John Curtin Sch Med Res, Div Immunol & Genet, Canberra, ACT 2601, Australia

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 03期

基金：

加拿大健康研究院;

关键词：

CD28; family; TNFR family; costimulation; viruses; T cells;

D O I：

10.1016/j.smim.2004.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1 BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：185 / 196

页数：12

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