IN-VIVO VERSUS IN-VITRO ASSAYS FOR ASSESSMENT OF T-CELL AND B-CELL FUNCTION

被引:30
作者
BACHMANN, MF [1 ]
KUNDIG, TM [1 ]
机构
[1] PRINCESS MARGARET HOSP, ONTARIO CANC INST, DEPT MED BIOPHYS, TORONTO M4X 1K9, ONTARIO, CANADA
关键词
D O I
10.1016/0952-7915(94)90108-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
As mice deficient in a particular gene provide an increasing number of novel in vivo models, in vivo assays that examine immune function are becoming a central issue. We found that the sensitivities of in vivo and in vitro assays are strikingly different. These differences have important implications for the interpretation and biological relevance of results.
引用
收藏
页码:320 / 326
页数:7
相关论文
共 33 条
  • [1] T4+ T-HELPER CELL-FUNCTION INVIVO - DIFFERENTIAL REQUIREMENT FOR INDUCTION OF ANTIVIRAL CYTO-TOXIC T-CELL AND ANTIBODY-RESPONSES
    AHMED, R
    BUTLER, LD
    BHATTI, L
    [J]. JOURNAL OF VIROLOGY, 1988, 62 (06) : 2102 - 2106
  • [2] FORMALIN INACTIVATION OF VESICULAR STOMATITIS-VIRUS IMPAIRS T-CELL- BUT NOT T-HELP-INDEPENDENT B-CELL RESPONSES
    BACHMANN, MF
    KUNDIG, TM
    KALBERER, CP
    HENGARTNER, H
    ZINKERNAGEL, RM
    [J]. JOURNAL OF VIROLOGY, 1993, 67 (07) : 3917 - 3922
  • [3] THE INFLUENCE OF ANTIGEN ORGANIZATION ON B-CELL RESPONSIVENESS
    BACHMANN, MF
    ROHRER, UH
    KUNDIG, TM
    BURKI, K
    HENGARTNER, H
    ZINKERNAGEL, RM
    [J]. SCIENCE, 1993, 262 (5138) : 1448 - 1451
  • [4] BINDER D, 1991, J IMMUNOL, V146, P4301
  • [5] COMPARISON OF THE SENSITIVITY OF IN-VIVO AND IN-VITRO ASSAYS FOR DETECTION OF ANTIVIRAL CYTOTOXIC T-CELL ACTIVITY
    CASTELMUR, I
    DIPAOLO, C
    BACHMANN, MF
    HENGARTNER, H
    ZINKERNAGEL, RM
    KUNDIG, TM
    [J]. CELLULAR IMMUNOLOGY, 1993, 151 (02) : 460 - 466
  • [6] VIRUS-INFECTIONS IN MICE WITH TARGETED GENE DISRUPTIONS
    DOHERTY, PC
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (04) : 479 - 483
  • [7] IMMUNE-RESPONSE AGAINST LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION IN MICE WITHOUT CD8-EXPRESSION
    FUNGLEUNG, WP
    KUNDIG, TM
    ZINKERNAGEL, RM
    MAK, TW
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (06) : 1425 - 1429
  • [8] CD8 IS NEEDED FOR DEVELOPMENT OF CYTOTOXIC T-CELLS BUT NOT HELPER T-CELLS
    FUNGLEUNG, WP
    SCHILHAM, MW
    RAHEMTULLA, A
    KUNDIG, TM
    VOLLENWEIDER, M
    POTTER, J
    VANEWIJK, W
    MAK, TW
    [J]. CELL, 1991, 65 (03) : 443 - 449
  • [9] IMMUNE-RESPONSE IN MICE THAT LACK THE INTERFERON-GAMMA RECEPTOR
    HUANG, S
    HENDRIKS, W
    ALTHAGE, A
    HEMMI, S
    BLUETHMANN, H
    KAMIJO, R
    VILCEK, J
    ZINKERNAGEL, RM
    AGUET, M
    [J]. SCIENCE, 1993, 259 (5102) : 1742 - 1745
  • [10] NORMAL B-LYMPHOCYTE DEVELOPMENT BUT IMPAIRED T-CELL MATURATION IN CD45-EXON6 PROTEIN-TYROSINE-PHOSPHATASE DEFICIENT MICE
    KISHIHARA, K
    PENNINGER, J
    WALLACE, VA
    KUNDIG, TM
    KAWAI, K
    WAKEHAM, A
    TIMMS, E
    PFEFFER, K
    OHASHI, PS
    THOMAS, ML
    FURLONGER, C
    PAIGE, CJ
    MAK, TW
    [J]. CELL, 1993, 74 (01) : 143 - 156