Pathogenomics of mobile genetic elements of toxigenic bacteria

被引：32

作者：

Hacker, J

Hochhut, B

Middendorf, B

Schneider, G

Buchrieser, C

Gottschalk, G

Dobrindt, U

机构：

[1] Univ Wurzburg, Inst Mol Biol Infect Dis, D-97070 Wurzburg, Germany

[2] Inst Pasteur, Lab Genom Microorganismes Pathogenes, Paris, France

[3] Gottingen Genom Lab, Inst Microbiol & Genet, Gottingen, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2004年 / 293卷 / 7-8期

关键词：

pathogenicity islands; genomic islands; pathogenomics; toxigenic bacteria;

D O I：

10.1078/1438-4221-00290

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The growing knowledge of genetic diversity and whole genome organization in bacteria shows that pathogenicity islands (PAIs) represent a subtype of a more general genetic element, termed genomic island (GEI), which is widespread among pathogenic and nonpathogenic microbes. These findings mirror the importance of horizontal gene transfer, genome reduction and recombination events as fundamental mechanisms involved in evolution of bacterial variants. GEIs are part of the flexible gene pool and carry selfish genes, but also determinants which may be beneficial under certain conditions thus increasing bacterial fitness and consequently their survival or transmission. In this review, we focus on the role of mobile genetic elements that may also contain toxin-encoding genes for genome variability and evolution of bacteria.

引用

页码：453 / 461

页数：9

共 49 条

[11] Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays [J].

Dobrindt, U ;

Agerer, F ;

Michaelis, K ;

Janka, A ;

Buchrieser, C ;

Samuelson, M ;

Svanborg, C ;

Gottschalk, G ;

Karch, H ;

Hacker, J .

JOURNAL OF BACTERIOLOGY, 2003, 185 (06) :1831-1840

[12] Genetic structure and distribution of four pathogenicity islands (PAI I536 to PAI IV536) of uropathogenic Escherichia coli strain 536 [J].

Dobrindt, U ;

Blum-Oehler, G ;

Nagy, G ;

Schneider, G ;

Johann, A ;

Gottschalk, G ;

Hacker, J .

INFECTION AND IMMUNITY, 2002, 70 (11) :6365-6372

[13]

Dobrindt U, 2002, CURR TOP MICROBIOL, V264, P157

[14] S-fimbria-encoding determinant sfaI is located on pathogenicity island III536 of uropathogenic Escherichia coli strain 536 [J].

Dobrindt, U ;

Blum-Oehler, G ;

Hartsch, T ;

Gottschalk, G ;

Ron, EZ ;

Fünfstück, R ;

Hacker, J .

INFECTION AND IMMUNITY, 2001, 69 (07) :4248-4256

[15]

Dobrindt U, 2000, INT J MED MICROBIOL, V290, P307

[16] Characterization of a putative pathogenicity island from bovine Staphylococcus aureus encoding multiple superantigens [J].

Fitzgerald, JR ;

Monday, SR ;

Foster, TJ ;

Bohach, GA ;

Hartigan, PJ ;

Meaney, WJ ;

Smyth, CJ .

JOURNAL OF BACTERIOLOGY, 2001, 183 (01) :63-70

[17] WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD [J].

FLEISCHMANN, RD ;

ADAMS, MD ;

WHITE, O ;

CLAYTON, RA ;

KIRKNESS, EF ;

KERLAVAGE, AR ;

BULT, CJ ;

TOMB, JF ;

DOUGHERTY, BA ;

MERRICK, JM ;

MCKENNEY, K ;

SUTTON, G ;

FITZHUGH, W ;

FIELDS, C ;

GOCAYNE, JD ;

SCOTT, J ;

SHIRLEY, R ;

LIU, LI ;

GLODEK, A ;

KELLEY, JM ;

WEIDMAN, JF ;

PHILLIPS, CA ;

SPRIGGS, T ;

HEDBLOM, E ;

COTTON, MD ;

UTTERBACK, TR ;

HANNA, MC ;

NGUYEN, DT ;

SAUDEK, DM ;

BRANDON, RC ;

FINE, LD ;

FRITCHMAN, JL ;

FUHRMANN, JL ;

GEOGHAGEN, NSM ;

GNEHM, CL ;

MCDONALD, LA ;

SMALL, KV ;

FRASER, CM ;

SMITH, HO ;

VENTER, JC .

SCIENCE, 1995, 269 (5223) :496-512

[18] Prokaryotic chromosomes and disease [J].

Hacker, J ;

Hentschel, U ;

Dobrindt, U .

SCIENCE, 2003, 301 (5634) :790-793

[19] Ecological fitness, genomic islands and bacterial pathogenicity - A Darwinian view of the evolution of microbes [J].

Hacker, J ;

Carniel, E .

EMBO REPORTS, 2001, 2 (05) :376-381

[20]

Hayashi T, 2001, DNA RES, V8, P11, DOI 10.1093/dnares/8.1.11

← 1 2 3 4 5 →