Geminal hydroxy phosphonate derivatives of nucleosides:: A novel class of nucleoside 5′-monophosphate analogues

被引：23

作者：

Králíková, S ^{[1
]}

Budesínsky, M ^{[1
]}

Masojídková, M ^{[1
]}

Rosenberg, I ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)02107-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel type of phosphonate-based, isopolar, nonisosteric 5'-nucleotide analogue, the nucleoside 5'-hydroxy phosphonates, was prepared by Abramov nucleophilic addition of various phosphorous acid esters to nucleoside 5'-aldehydes. The newly formed compounds are distinguished by chirality of the 5'-carbon atom. The configuration of the 5'-epimers was assigned from NMR spectra. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：955 / 958

页数：4

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