P-selectin in haemostasis

被引:153
作者
André, P [1 ]
机构
[1] Portola Pharmaceut Inc, San Francisco, CA 94080 USA
关键词
P-selectin; P-selectin glycoprotein ligand-1; microparticles; thrombosis; atherosclerosis;
D O I
10.1111/j.1365-2141.2004.05032.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
During the past decade, interrelationships between inflammation and thrombosis have been the subject of extensive works, and it is now commonly recognized that inflammation (notably leucocyte recruitment) directly affects thrombosis, and that thrombosis also constitutes a pro-inflammatory event. This tight link is partly attributable to P-selectin, which is functional not only when expressed on the surface of activated platelets and endothelial cells, but also when shed, generating its soluble form, termed sP-selectin. In this review, we will provide an overview of the relative roles of the different compartments of P-selectin (platelet, endothelial cell, plasma) in haemostasis and vascular pathologies, and the potential therapeutic benefits achievable in targeting this molecule.
引用
收藏
页码:298 / 306
页数:9
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