Absence of seven human herpesviruses, including HHV-6, by polymerase chain reaction in CSF and blood from patients with multiple sclerosis and optic neuritis

被引:77
作者
Martin, C
Enbom, M
Soderstrom, M
Fredrikson, S
Dahl, H
Lycke, J
Bergstrom, T
Linde, A
机构
[1] SWEDISH INST INFECT DIS CONTROL,DEPT VIROL,STOCKHOLM,SWEDEN
[2] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT OPHTHALMOL,STOCKHOLM,SWEDEN
[3] UNIV GOTHENBURG,DEPT NEUROL,GOTHENBURG,SWEDEN
[4] UNIV GOTHENBURG,DEPT CLIN VIROL,GOTHENBURG,SWEDEN
来源
ACTA NEUROLOGICA SCANDINAVICA | 1997年 / 95卷 / 05期
关键词
herpesvirus; HHV-6; multiple sclerosis; cerebrospinal fluid; polymerase chain reaction;
D O I
10.1111/j.1600-0404.1997.tb00210.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Several members of the herpesvirus family have been implicated in the pathogenesis of multiple sclerosis (MS). Recently, HHV-6 viral antigen has been demonstrated in association to MS plaques, as well as DNA from human herpesvirus 6 (HHV-6) in cerebrospinal fluid from a few MS patients by polymerase chain reaction (PCR). In the present study, CSF from patients with MS, optic neuritis and other neurological diseases, as well as consecutive CSF and serum samples from MS patients included in a clinical trial with acyclovir, were analysed by nested PCR for the presence of DNA from herpes simplex virus 1 and 2, Epstein-Barr virus, varicella tester virus, cytomegalovirus, human herpesvirus 6 and 7. No virus DNA was found in any CSF (n=115) or serum (n=116) sample. These findings argue against a continuous disseminated herpesvirus infection in MS, but do not rule out a lesion-associated, low-grade herpesvirus infection within the MS brain.
引用
收藏
页码:280 / 283
页数:4
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