TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy

被引：147

作者：

Wajant, H ^{[1
]}

Pfizenmaier, K ^{[1
]}

Scheurich, P ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Cell Biol & Immunol, D-70569 Stuttgart, Germany

来源：

APOPTOSIS | 2002年 / 7卷 / 05期

关键词：

apoptosis; cancer; cell death; TRAIL; TRAIL-R1; TRAIL-R2;

D O I：

10.1023/A:1020039225764

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TNF-related apoptosis-inducing ligand (TRAIL/APO-2L) is a typical member of the TNF ligand family that induces apoptosis by activating the death receptors TRAIL-R1 and TRAIL-R2. TRAIL has attracted great attention in recent years as a promising anti cancer reagent because recombinant soluble TRAIL derivatives induce apoptosis in a broad range of tumor cells but not or only rarely in non-transformed cells. In this review we will address the putative role of TRAIL in cancer treatment in the light of the emerging importance of TRAIL in tumor surveillance and discuss the molecular basis of the cooperation of TRAIL and chemotherapeutic drugs. In particular, we debate controversial data in the literature concerning the cytotoxicity of different TRAIL derivatives on primary human cells.

引用

页码：449 / 459

页数：11

共 135 条

[61] Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis [J].