Genetic ancestry and the search for personalized genetic histories

被引:135
作者
Shriver, MD [1 ]
Kittles, RA
机构
[1] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA
[2] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrg1405
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Public demand and the development of large public and private databases of genetic information across human populations has encouraged the development of the new and rapidly growing field of genetic ancestry testing. Both the promise of the science that underlies this field and a lack of a full understanding of its limitations have fuelled the increased public interest in genetic ancestry testing.
引用
收藏
页码:611 / U3
页数:8
相关论文
共 74 条
[31]   Mutations at Y-STR loci: implications for paternity testing and forensic analysis [J].
Kayser, M ;
Sajantila, A .
FORENSIC SCIENCE INTERNATIONAL, 2001, 118 (2-3) :116-121
[32]   An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations [J].
Kayser, M ;
Krawczak, M ;
Excoffier, L ;
Dieltjes, P ;
Corach, D ;
Pascali, V ;
Gehrig, C ;
Bernini, LF ;
Jespersen, J ;
Bakker, E ;
Roewer, L ;
de Knijff, P .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (04) :990-1018
[33]   Dual origins of Finns revealed by Y chromosome haplotype variation [J].
Kittles, RA ;
Perola, M ;
Peltonen, L ;
Bergen, AW ;
Aragon, RA ;
Virkkunen, M ;
Linnoila, M ;
Goldman, D ;
Long, JC .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1171-1179
[34]  
Lee S S, 2001, Yale J Health Policy Law Ethics, V1, P33
[35]  
Lessig Ruediger, 2003, Leg Med (Tokyo), V5 Suppl 1, pS160, DOI 10.1016/S1344-6223(02)00100-1
[36]   STABLE LINKAGE DISEQUILIBRIUM WITHOUT EPISTASIS IN SUBDIVIDED POPULATION [J].
LI, WH ;
NEI, M .
THEORETICAL POPULATION BIOLOGY, 1974, 6 (02) :173-183
[37]   The structure of diversity within new world mitochondrial DNA haplogroups: Implications for the prehistory of North America [J].
Malhi, RS ;
Eshleman, JA ;
Greenberg, JA ;
Weiss, DA ;
Shook, BAS ;
Kaestle, FA ;
Lorenz, JG ;
Kemp, BM ;
Johnson, JR ;
Smith, DG .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (04) :905-919
[38]  
McKeigue PM, 2000, GENET EPIDEMIOL, V19, P464, DOI 10.1002/1098-2272(200012)19:4<464::AID-GEPI17>3.0.CO
[39]  
2-M
[40]   Mapping genes that underlie ethnic differences in disease risk: Methods for detecting linkage in admixed populations, by conditioning on parental admixture [J].
McKeigue, PM .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (01) :241-251