Hemorrhage and VEGF expression in a case of primary CNS lymphoma

被引：35

作者：

Rubenstein, J

Fischbein, N

Aldape, K

Burton, E

Shuman, M

机构：

[1] Univ Calif San Francisco, Div Hematol Oncol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2002年 / 58卷 / 01期

关键词：

primary CNS lymphoma; hemorrhage; angiogenesis; vascular endothelial growth factor;

D O I：

10.1023/A:1015887312455

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hemorrhage at presentation in primary CNS lymphoma is exceedingly rare. We describe a patient with primary CNS lymphoma who presented with seizures and was found to have an intracerebral hemorrhage which prompted a cerebral angiogram. Ultimately pathologic evaluation of the lesion revealed a highly cellular B-cell lymphoma with marked hypervascularity and intense expression of vascular endothelial growth factor (VEGF). A review of four other recent cases of primary CNS lymphoma at our institution revealed less-intense VEGF immunoreactivity. This is the first report of VEGF expression in primary CNS lymphoma. The potential significance of VEGF expression with respect to the biology of this tumor is discussed.

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收藏

页码：53 / 56

页数：4

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