Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia
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作者:
Bachmayer, Nora
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机构:Stockholm Univ, Wenner Gren Inst, Arrhenius Labs Nat Sci F5, Dept Immunol, S-10691 Stockholm, Sweden
Bachmayer, Nora
Hamad, Rangeen Rafik
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机构:Stockholm Univ, Wenner Gren Inst, Arrhenius Labs Nat Sci F5, Dept Immunol, S-10691 Stockholm, Sweden
Hamad, Rangeen Rafik
Liszka, Lucie
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机构:Stockholm Univ, Wenner Gren Inst, Arrhenius Labs Nat Sci F5, Dept Immunol, S-10691 Stockholm, Sweden
Liszka, Lucie
Bremme, Katarina
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机构:Stockholm Univ, Wenner Gren Inst, Arrhenius Labs Nat Sci F5, Dept Immunol, S-10691 Stockholm, Sweden
Bremme, Katarina
Sverremark-Ekstrom, Eva
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机构:Stockholm Univ, Wenner Gren Inst, Arrhenius Labs Nat Sci F5, Dept Immunol, S-10691 Stockholm, Sweden
Sverremark-Ekstrom, Eva
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[1] Stockholm Univ, Wenner Gren Inst, Arrhenius Labs Nat Sci F5, Dept Immunol, S-10691 Stockholm, Sweden
[2] Karolinska Univ Hosp, Karolinska Inst, Dept Women & Child Hlth, Div Obstet & Gynecol, Stockholm, Sweden
Natural killer (NK) cells are the most abundant lymphocyte population at the maternal-fetal interface. They are suggested to be important during placentation by controlling trophoblast invasion. If placentation is suboptimal, pre-eclampsia can occur. Decidual NK (dNK) cells were examined at delivery in 46 women, 22 pre-eclamptic women and 24 healthy controls, by staining for CD56 and CD94 with immunohistochemistry (IHC). Furthermore, we investigated the placental expression and the serum levels of the NK-cell activating cytokines interleukin(IL)-12, IL-15, IL-18 and the anti-inflammatory cytokine IL-10 by IHC and enzyme-linked immunosorbent assay (ELISA), respectively. Pre-eclamptic women had higher number of CD56(+) and CD94(+) cells in the decidua, indicating an altered receptor expression of dNK cells. We also demonstrate for the first time that the villous trophoblasts show strong immunostaining for IL-12 in placentae from healthy controls, while women suffering from pre-eclampsia have significantly less IL-12. However, pre-eclamptic women had significantly elevated IL-12 and IL-15 levels in serum. Results show increased numbers and altered phenotype of dNK cells in pre-eclampsia, supporting the importance of these cells for a healthy pregnancy. The altered receptor expression of dNK cells together with diminished placental IL-12 expression could implicate an altered NK cell-regulation in pre-eclampsia.
机构:
Vilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, LithuaniaVilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, Lithuania
Eidukaite, A
;
Siaurys, A
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Vilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, LithuaniaVilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, Lithuania
Siaurys, A
;
Tamosiunas, V
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Vilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, LithuaniaVilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, Lithuania
机构:
Vilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, LithuaniaVilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, Lithuania
Eidukaite, A
;
Siaurys, A
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机构:
Vilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, LithuaniaVilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, Lithuania
Siaurys, A
;
Tamosiunas, V
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Vilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, LithuaniaVilnius State Univ, Inst Immunol, Dept Mol Immunol, LT-2021 Vilnius, Lithuania