In Vitro Activities of Echinocandins against Candida krusei Determined by Three Methods: MIC and Minimal Fungicidal Concentration Measurements and Time-Kill Studies

被引：33

作者：

Canton, Emilia ^{[1
]}

Peman, Javier ^{[2
]}

Valentin, Amparo ^{[1
]}

Espinel-Ingroff, Ana ^{[3
]}

Gobernado, Miguel ^{[2
]}

机构：

[1] Hosp Univ La Fe, Unidad Microbiol Expt, Ctr Invest, Valencia 46009, Spain

[2] Hosp Univ La Fe, Microbiol Serv, Valencia 46009, Spain

[3] VCU Med Ctr, Div Infect Dis, Richmond, VA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 07期

关键词：

ANTIFUNGAL SUSCEPTIBILITY; AMPHOTERICIN-B; CASPOFUNGIN; ANIDULAFUNGIN; PHARMACOKINETICS; EPIDEMIOLOGY; FLUCONAZOLE; LY-303366; BLOOD;

D O I：

10.1128/AAC.00160-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times to reach 99.9% growth reduction were 19.1 +/- 18.2 h (mean +/- standard deviation) for 2 mg/liter anidulafungin, 37.4 +/- 8.8 h for 2 mg/liter caspofungin, and 30.7 +/- 12.2 h for 1 mg/liter micafungin. Anidulafungin exhibited the highest time-kill rate, followed by micafungin. The three echinocandins showed fungicidal activity at concentrations reached in serum.

引用

页码：3108 / 3111

页数：4

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