A Chemical Approach to Immunoprotein Engineering: Chemoselective Functionalization of Thioester Proteins in Their Native State

被引：5

作者：

Cole, Michael A. ^{[1
]}

Tully, Sarah E. ^{[1
,3
,4
]}

Dodds, Alister W. ^{[2
]}

Arnold, James N. ^{[1
]}

Boldt, Grant E. ^{[1
]}

Sim, Robert B. ^{[2
]}

Offer, John ^{[1
]}

Wentworth, Paul, Jr. ^{[1
,3
,4
]}

机构：

[1] Univ Oxford, Dept Biochem, Scripps Oxford Lab, Oxford OX1 3QU, England

[2] Univ Oxford, Dept Biochem, MRC Immunochem Unit, Oxford OX1 3QU, England

[3] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 08期

基金：

英国医学研究理事会;

关键词：

activity-based protein profiling; hydrazides; peptides; proteins; thioesters; ALTERNATIVE COMPLEMENT PATHWAY; CONFORMATIONAL-CHANGES; PUTATIVE THIOESTER; COMPONENT C3; C-3; BINDING; ALPHA-2-MACROGLOBULIN; ACQUISITION; CONVERTASE; ACTIVATION;

D O I：

10.1002/cbic.200900168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1340 / 1343

页数：4

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