Identification of a novel HLA-B allele (B*4202) in a Saudi Arabian family with Behcet's disease

被引：7

作者：

Ando, H

Mizuki, N

Ohno, S

Tabbara, KF

Taguchi, S

Yamazaki, M

Mizuki, N

Miyata, Y

Wakisaka, K

Inoko, H

机构：

[1] TOKAI UNIV,SCH MED,DEPT GENET INFORMAT,DIV MOL LIFE SCI,ISEHARA,KANAGAWA 25911,JAPAN

[2] JAPANESE RED CROSS SAITAMA BLOOD CTR,KANAGAWA,JAPAN

[3] YOKOHAMA CITY UNIV,SCH MED,DEPT OPHTHALMOL,KANAGAWA,JAPAN

[4] KING SAUD UNIV,COLL MED,DEPT OPHTHALMOL,RIYADH 11461,SAUDI ARABIA

[5] FUJIYA CO LTD,BIOSCI RES LAB,KANAGAWA,JAPAN

[6] YOKOHAMA CITY UNIV,SCH MED,DEPT MAXILLOFACIAL SURG,KANAGAWA,JAPAN

来源：

TISSUE ANTIGENS | 1997年 / 49卷 / 05期

关键词：

HLA-B42; HLA-B*4202; HLA-B42AND; HLA-B*4201; Saudi Arabian; SEQUENCES; LOCUS;

D O I：

10.1111/j.1399-0039.1997.tb02792.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A new HLA-B antigen, tentatively called HLA-B42AND, was identified as a B42 serologic variant in a Saudi Arabian family. DNA sequencing analysis of the second and third exon of this new B allele revealed that B42AND was identical to B*4201 except for a single T to C substitution at position 97 of exon 2. This substitution results in histidine (CAC) at codon 9 in B42AND instead of tyrosine (TAC) in B*4201. The antigen frequency of B42AND in a Saudi Arabian population was around 10%. This novel B42AND has officially been named HLA-B*4202.

引用

页码：526 / 528

页数：3

共 9 条

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