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A UNIQUELY HIGH-LEVEL OF RECOMBINATION AT THE HLA-B LOCUS

被引：108
作者：
MCADAM, SN
BOYSON, JE
LIU, XM
GARBER, TL
HUGHES, AL
BONTROP, RE
WATKINS, DI
机构：
[1] UNIV WISCONSIN,WISCONSIN REG PRIMATE RES CTR,MADISON,WI 53715
[2] UNIV WISCONSIN,DEPT PATHOL,MADISON,WI 53715
[3] UNIV MARYLAND,BALTIMORE,MD 21201
[4] PENN STATE UNIV,DEPT BIOL,MUELLER LAB 208,UNIV PK,PA 16802
[5] NEDERLANDSE CENT ORG TOEGEPAST NAT WETENSCHAPPELI,MED BIOL LABS,2280 HV RIJSWIJK,NETHERLANDS
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 13期
关键词：
CHIMPANZEE; BONOBO; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I; EVOLUTION;
D O I：
10.1073/pnas.91.13.5893
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Major histocompatibility complex (MHC) loci are some of the most polymorphic genes in the animal kingdom. Recently, it has been suggested that although most of the human MHC loci are relatively stable, the HLA-B locus can undergo rapid changes, especially in isolated populations. To investigate the mechanisms of HLA-B evolution we have compared the sequences of 19 HLA-B homologues from chimpanzees and bonobos to 65 HLA-B sequences. Analysis of the chimpanzee and bonobo HLA-B homologues revealed that despite obvious similarities between chimpanzee and human alleles in exon 2, there was little conservation of exon 3 between humans and the two chimpanzee species. This finding suggests that, unlike all other HLA loci, recombination has characterized the HLA-B locus and its homologues for over 5 million years.
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页码：5893 / 5897
页数：5
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