Signaling via vascular endothelial growth factor receptors

被引：244

作者：

Petrova, TV ^{[1
]}

Makinen, T ^{[1
]}

Alitalo, K ^{[1
]}

机构：

[1] Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, SF-00014 Helsinki, Finland

来源：

EXPERIMENTAL CELL RESEARCH | 1999年 / 253卷 / 01期

基金：

芬兰科学院;

关键词：

angiogenesis; endothelial cells; receptor tyrosine kinases; signal transduction; VEGF receptors; VEGF;

D O I：

10.1006/excr.1999.4707

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis, or development of blood vessels from preexisting vasculature, has important functions under both normal and pathophysiological conditions. Vascular endothelial growth factor receptors 1-3, also known as fit-1, KDR, and flt-4, are endothelial cell-specific receptor tyrosine kinases which serve as key mediators of the angiogenic responses. The review focuses on the signaling pathways that are initiated from these receptors and the recently identified VEGF coreceptor neuroplilin-1. (C) 1999 Academic Press.

引用

页码：117 / 130

页数：14

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