A Closer Look at Mucosal Inflammation in Irritable Bowel Syndrome: Sex-and Gender-Related Disparities-Quantity, Quality, or Both?

被引:5
作者
Alonso, Carmen [1 ]
Santos, Javier [1 ]
机构
[1] Univ Autonoma Barcelona, Hosp Univ Vall dHebron,Dept Med, Dept Gastroenterol,Digest Dis Res Unit, Inst Recerca Vall dHebron,Neuroimmunogastroentero, Barcelona 08035, Spain
关键词
IMMUNE ACTIVATION; IBS PATIENTS; MAST-CELLS; STRESS; PAIN; RESPONSES;
D O I
10.1038/ajg.2008.105
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Irritable bowel syndrome remains a bothersome and frustrating disorder that imposes a heavy and growing socio-economic toll on its sufferers, two-thirds of whom are women, and on health care systems. The biomedical community must take a giant step forward into the discipline of women's gastrointestinal health. Efforts and accomplishments, such as the one reported in this month's issue by Cremon et al., are certainly welcome.
引用
收藏
页码:401 / 403
页数:3
相关论文
共 38 条
[1]
Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome [J].
Aerssens, Jeroen ;
Camilleri, Michael ;
Talloen, Willem ;
Thielemans, Leen ;
Goehlmann, Hinrich W. H. ;
Van den Wyngaert, Ilse ;
Thielemans, Theo ;
De Hoogt, Ronald ;
Andrews, Christopher N. ;
Bharucha, Adil E. ;
Carlson, Paula J. ;
Busciglio, Irene ;
Burton, Duane D. ;
Smyrk, Thomas ;
Urrutia, Raul ;
Coulie, Bernard .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2008, 6 (02) :194-205
[2]
Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation [J].
Alonso, Carmen ;
Guilarte, Mar ;
Vicario, Maria ;
Ramos, Laura ;
Ramadan, Ziad ;
Antolin, Maria ;
Martinez, Cristina ;
Rezzi, Serge ;
Saperas, Esteban ;
Kochhar, Sunil ;
Santos, Javier ;
Malagelada, Juan Ramon .
GASTROENTEROLOGY, 2008, 135 (01) :163-172
[3]
[Anonymous], 2001, Exploring the Biological Contributions to Human Health: Does Sex Matter? Sex Begins in the Womb
[4]
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome [J].
Barbara, G ;
Stanghellini, V ;
De Giorgio, R ;
Cremon, C ;
Cottrell, GS ;
Santini, D ;
Pasquinelli, G ;
Morselli-Labate, AM ;
Grady, EF ;
Bunnett, NW ;
Collins, SM ;
Corinalidesi, R .
GASTROENTEROLOGY, 2004, 126 (03) :693-702
[5]
Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome [J].
Barbara, Giovanni ;
Wang, Bingxian ;
Stanghellini, Vincenzo ;
De Giorgio, Roberto ;
Cremon, Cesare ;
Di Nardo, Giovanni ;
Trevisani, Marcello ;
Campi, Barbara ;
Geppetti, Pierangelo ;
Tonini, Marcello ;
Bunnett, Nigel W. ;
Grundy, David ;
Corinaldesi, Roberto .
GASTROENTEROLOGY, 2007, 132 (01) :26-37
[6]
Sex differences and estrogen modulation of the cellular immune response after injury [J].
Bird, Melanie D. ;
Karavitis, John ;
Kovacs, Elizabeth J. .
CELLULAR IMMUNOLOGY, 2008, 252 (1-2) :57-67
[7]
Role for protease activity in visceral pain in irritable bowel syndrome [J].
Cenac, Nicolas ;
Andrews, Christopher N. ;
Holzhausen, Marinella ;
Chapman, Kevin ;
Cottrell, Graeme ;
Andrade-Gordon, Patricia ;
Steinhoff, Martin ;
Barbara, Giovanni ;
Beck, Paul ;
Bunnett, Nigel W. ;
Sharkey, Keith A. ;
Ferraz, Jose Geraldo P. ;
Shaffer, Eldon ;
Vergnolle, Nathalie .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (03) :636-647
[8]
Activation of the mucosal immune system in irritable bowel syndrome [J].
Chadwick, VS ;
Chen, WX ;
Shu, DR ;
Paulus, B ;
Bethwaite, P ;
Tie, A ;
Wilson, I .
GASTROENTEROLOGY, 2002, 122 (07) :1778-1783
[9]
Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome [J].
Chang, Lin ;
Mayer, Emeran A. ;
Labus, Jennifer S. ;
Schmulson, Max ;
Lee, Oh Young ;
Olivas, Teresa I. ;
Stains, Jean ;
Naliboff, Bruce D. .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2006, 291 (02) :R277-R284
[10]
Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders [J].
Chang, Lin ;
Toner, Brenda B. ;
Fukudo, Shin ;
Guthrie, Elspeth ;
Locke, G. Richard ;
Norton, Nancy J. ;
Sperber, Ami D. .
GASTROENTEROLOGY, 2006, 130 (05) :1435-1446