Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients

被引：92

作者：

Leung, J. M.

Sands, L. P.

Rico, M.

Petersen, K. L.

Rowbotham, M. C.

Dahl, J. B.

Ames, C.

Chou, D.

Weinstein, P.

机构：

[1] Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

[4] Purdue Univ, Sch Nursing, W Lafayette, IN 47907 USA

[5] Glostrup Univ Hosp, Glostrup, Denmark

来源：

NEUROLOGY | 2006年 / 67卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000233831.87781.a9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.

引用

收藏

页码：1251 / 1253

页数：3

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