The road much traveled: trafficking in the cell nucleus

被引：80

作者：

Gorski, Stanislaw A. ^{[1
]}

Dundr, Miroslav ^{[1
]}

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2006年 / 18卷 / 03期

关键词：

D O I：

10.1016/j.ceb.2006.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Trafficking of RNA molecules and proteins within the cell nucleus is central to genome function. Recent work has revealed the nature of RNA and protein motion within the nucleus and across the nuclear membrane. These studies have given insight into how molecules find their destinations within the nucleus and have uncovered some of the structural properties of the nuclear microenvironment. Control of RNA and protein trafficking is now emerging as a physiological regulatory mechanism in gene expression and nuclear function.

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页码：284 / 290

页数：7

相关论文

共 61 条

[1] Nucleolar proteome dynamics [J].

Andersen, JS ;

Lam, YW ;

Leung, AKL ;

Ong, SE ;

Lyon, CE ;

Lamond, AI ;

Mann, M .

NATURE, 2005, 433 (7021) :77-83

[2] Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors [J].

Bentley, DL .

CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (03) :251-256

[3] GENE GATING - A HYPOTHESIS [J].

BLOBEL, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8527-8529

[4] Intracellular macromolecular mobility measured by fluorescence recovery after photobleaching with confocal laser scanning microscopes [J].

Braga, J ;

Desterro, JMP ;

Carmo-Fonseca, M .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (10) :4749-4760

[5] The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive [J].

Calapez, A ;

Pereira, HM ;

Calado, A ;

Braga, J ;

Rino, J ;

Carvalho, C ;

Tavanez, JP ;

Wahle, E ;

Rosa, AC ;

Carmo-Fonseca, M .

JOURNAL OF CELL BIOLOGY, 2002, 159 (05) :795-805

[6] Macromolecular mobility inside the cell nucleus [J].

Carmo-Fonseca, M ;

Platani, M ;

Swedlow, JR .

TRENDS IN CELL BIOLOGY, 2002, 12 (11) :491-495

[7] Competition between histone H1 and HMGN proteins for chromatin binding site [J].

Catez, F ;

Brown, DT ;

Misteli, T ;

Bustin, M .

EMBO REPORTS, 2002, 3 (08) :760-766

[8] Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells [J].

Chen, DY ;

Huang, S .

JOURNAL OF CELL BIOLOGY, 2001, 153 (01) :169-176

[9] Maintenance of stable heterochromatin domains by dynamic HP1 binding [J].

Cheutin, T ;

McNairn, AJ ;

Jenuwein, T ;

Gilbert, DM ;

Singh, PB ;

Misteli, T .

SCIENCE, 2003, 299 (5607) :721-725

[10] Chromosome territories, nuclear architecture and gene regulation in mammalian cells [J].

Cremer, T ;

Cremer, C .

NATURE REVIEWS GENETICS, 2001, 2 (04) :292-301

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