Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model

被引：41

作者：

Boldt, Grant E.

Eubanks, Lisa M.

Janda, Kim D.

机构：

[1] Scripps Res Inst, Worm Inst Res Med, Dept Chem, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Worm Inst Res Med, Dept Immunol, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 29期

关键词：

D O I：

10.1039/b603099h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we describe a small-molecule, non-peptidic, inhibitor for botulinum neurotoxin A protease, that displays for the first time efficacy in a cell-based assay.

引用

页码：3063 / 3065

页数：3

共 16 条

[1] Genetic and immunological comparison of anti-botulinum type A antibodies from immune and non-immune human phage libraries [J].

Amersdorfer, P ;

Wong, C ;

Smith, T ;

Chen, S ;

Deshpande, S ;

Sheridan, R ;

Marks, JD .

VACCINE, 2002, 20 (11-12) :1640-1648

[2] Partial protection against botulinum B neurotoxin-induced blocking of exocytosis by a potent inhibitor of its metallopeptidase activity [J].

Anne, C ;

Turcaud, S ;

Blommaert, AGS ;

Darchen, F ;

Johnson, EA ;

Roques, BR .

CHEMBIOCHEM, 2005, 6 (08) :1375-1380

[3] Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry [J].

Boldt, GE ;

Kennedy, JP ;

Janda, KD .

ORGANIC LETTERS, 2006, 8 (08) :1729-1732

[4]

BOLDT GE, 2006, J COMB CHEM

[5] Substrate recognition strategy for botulinum neurotoxin serotype A [J].

Breidenbach, MA ;

Brunger, AT .

NATURE, 2004, 432 (7019) :925-929

[6] Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity [J].

Burnett, JC ;

Schmidt, JJ ;

Stafford, RG ;

Panchal, RG ;

Nguyen, TL ;

Hermone, AR ;

Vennerstrom, JL ;

McGrath, CF ;

Lane, DJ ;

Sausville, EA ;

Zaharevitz, DW ;

Gussio, R ;

Bavari, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 310 (01) :84-93

[7] Unique substrate recognition by botulinum neurotoxins serotypes A and E [J].

Chen, S ;

Barbieri, JT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (16) :10906-10911

[8] Vitamin B2-mediated cellular photoinhibition of botulinum neurotoxin A [J].

Eubanks, LM ;

Dickerson, TJ ;

Janda, KD .

FEBS LETTERS, 2005, 579 (24) :5361-5364

[9] The medicinal chemistry of botulinum, ricin and anthrax toxins [J].

Hicks, RP ;

Hartell, MG ;

Nichols, DA ;

Bhattacharjee, AK ;

van Hamont, JE ;

Skillman, DR .

CURRENT MEDICINAL CHEMISTRY, 2005, 12 (06) :667-690

[10] Improved solution- and solid-phase preparation of hydroxamic acids from esters [J].

Ho, CY ;

Strobel, E ;

Ralbovsky, J ;

Galemmo, RA .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (12) :4873-4875

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