Improved solution- and solid-phase preparation of hydroxamic acids from esters

被引:57
作者
Ho, CY [1 ]
Strobel, E [1 ]
Ralbovsky, J [1 ]
Galemmo, RA [1 ]
机构
[1] Johnson & Johnson Pharmaceut Res & Dev, Oncol Team, Drug Discovery, Spring House, PA 19446 USA
关键词
D O I
10.1021/jo050036f
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The addition of small amounts of solid KCN to solution and solid-phase esters in THF/MeOH/50% aqueous NH2OH increases the efficiency of their transformation to the corresponding hydroxamic acids.
引用
收藏
页码:4873 / 4875
页数:3
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