A novel linkage for the solid-phase synthesis of hydroxamic acids

被引：49

作者：

Bauer, U ^{[1
]}

Ho, WB ^{[1
]}

Koskinen, AMP ^{[1
]}

机构：

[1] UNIV OULU,DEPT CHEM,FI-90571 OULU,FINLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(97)01678-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel linkage for the solid-phase synthesis of hydroxamic acids is described and its facile application for the solid phase synthesis of peptidyl, succinyl and urea-type hydroxamic acids is illustrated. Cleavage is induced under mild acidic conditions by treatment with formic acid in THF, providing hydroxamic acids in high purity and fair to good yields. (C) 1997 Elsevier Science Ltd.

引用

页码：7233 / 7236

页数：4

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