共 88 条
Tumor and viral recognition by natural killer cells receptors
被引:131
作者:

Arnon, Tal I.
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机构:
Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel

Markel, Gal
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h-index: 0
机构:
Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel

Mandelboim, Ofer
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h-index: 0
机构:
Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel
机构:
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel
关键词:
D O I:
10.1016/j.semcancer.2006.07.005
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Natural killer (NK) cells destroy hazardous cells such as tumors and virus-infected cells immediately without the need for prior antigen stimulation. The activation of NK cells largely depends on the recently identified natural cytotoxic receptors (NCRs), which include three members: NKp46, NKp44 and NKp30. The NCRs are unique in their expression pattern that is almost conclusively confined to NK cells, and in their broad specificity towards a wide range of targets. However, very little is known about the ligands identity of the NCRs and so far the only ligands known are two virally derived molecules: the hemagglutinin protein of influenza viruses that directly binds and activates two of the NCRs; NKp46 and NKp44, and the human cytomegalovirus tegument protein, pp65, which binds the NKp30 receptor and inhibits its activation thus promoting survival of the virus. In this review we describe the function of the NCRs in various pathological conditions with a special emphasis on tumor targeting. (c) 2006 Elsevier Ltd. All rights reserved.
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页码:348 / 358
页数:11
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共 88 条
- [11] SEVERE HERPESVIRUS INFECTIONS IN AN ADOLESCENT WITHOUT NATURAL-KILLER CELLS[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (26) : 1731 - 1735BIRON, CA论文数: 0 引用数: 0 h-index: 0机构: UNIV MASSACHUSETTS,SCH MED,DEPT PEDIAT,55 LAKE AVE N,WORCESTER,MA 01655BYRON, KS论文数: 0 引用数: 0 h-index: 0机构: UNIV MASSACHUSETTS,SCH MED,DEPT PEDIAT,55 LAKE AVE N,WORCESTER,MA 01655SULLIVAN, JL论文数: 0 引用数: 0 h-index: 0机构: UNIV MASSACHUSETTS,SCH MED,DEPT PEDIAT,55 LAKE AVE N,WORCESTER,MA 01655
- [12] NK cells and NKT cells in innate defense against viral infections[J]. CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (04) : 458 - 464Biron, CA论文数: 0 引用数: 0 h-index: 0机构: Brown Univ, Dept Mol Microbiol & Immunol, Div Biol & Med, Providence, RI 02912 USA Brown Univ, Dept Mol Microbiol & Immunol, Div Biol & Med, Providence, RI 02912 USABrossay, L论文数: 0 引用数: 0 h-index: 0机构: Brown Univ, Dept Mol Microbiol & Immunol, Div Biol & Med, Providence, RI 02912 USA Brown Univ, Dept Mol Microbiol & Immunol, Div Biol & Med, Providence, RI 02912 USA
- [13] Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46[J]. JOURNAL OF IMMUNOLOGY, 2004, 173 (04) : 2392 - 2401Bloushtain, N论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelQimron, U论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelBar-Ilan, A论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelHershkovitz, O论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelGazit, R论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelFima, E论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelKorc, M论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelVlodavsky, I论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelBovin, NV论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, IsraelPorgador, A论文数: 0 引用数: 0 h-index: 0机构: Ben Gurion Univ Negev, Fac Hlth Sci, Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel
- [14] The human natural cytotoxicity receptors (NCR) that induce HLA class I-independent NK cell triggering[J]. HUMAN IMMUNOLOGY, 2000, 61 (01) : 1 - 6Bottino, C论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, ItalyBiassoni, R论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, ItalyMillo, R论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, ItalyMoretta, L论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, ItalyMoretta, A论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy
- [15] NKP44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence[J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (02) : 899 - 906Campbell, KS论文数: 0 引用数: 0 h-index: 0机构: Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USAYusa, S论文数: 0 引用数: 0 h-index: 0机构: Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USAKikuchi-Maki, A论文数: 0 引用数: 0 h-index: 0机构: Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USACatina, TL论文数: 0 引用数: 0 h-index: 0机构: Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Inst Canc Res, Div Basic Sci, Philadelphia, PA 19111 USA
- [16] The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity[J]. STRUCTURE, 2003, 11 (06) : 725 - 734Cantoni, C论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalyPonassi, M论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalyBiassoni, R论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalyConte, R论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalySpallarossa, A论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalyMoretta, A论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalyMoretta, L论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalyBolognesi, M论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, ItalyBordo, D论文数: 0 引用数: 0 h-index: 0机构: Ist Sci Studio & Cura Tumori, Lab Biol Strutt, I-16132 Genoa, Italy
- [17] NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) : 787 - 795Cantoni, C论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, ItalyBottino, C论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, ItalyVitale, M论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, ItalyPessino, A论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, ItalyAugugliaro, R论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, ItalyMalaspina, A论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, Italy论文数: 引用数: h-index:机构:Moretta, L论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, ItalyMoretta, A论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, ItalyBiassoni, R论文数: 0 引用数: 0 h-index: 0机构: Ctr Biotechnol Avanzate, Lab Immunopatol, I-16132 Genoa, Italy
- [18] Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors:: Consequences for the NK-mediated killing of dendritic cells[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 4120 - 4125Castriconi, R论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyCantoni, C论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyDella Chiesa, M论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyVitale, M论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyMarcenaro, E论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyConte, R论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyBiassoni, R论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyBottino, C论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyMoretta, L论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, ItalyMoretta, A论文数: 0 引用数: 0 h-index: 0机构: Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy
- [19] Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity[J]. NATURE MEDICINE, 2006, 12 (02) : 207 - 213Chan, CW论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USACrafton, E论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USAFan, HN论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USAFlook, J论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USAYoshimura, K论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USASkarica, M论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USABrockstedt, D论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USADubensky, TW论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USAStins, MF论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USALanier, LL论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USAPardoll, DM论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USAHousseau, F论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
- [20] NK cell and DC interactions[J]. TRENDS IN IMMUNOLOGY, 2004, 25 (01) : 47 - 52Cooper, MA论文数: 0 引用数: 0 h-index: 0机构: Ohio State Univ, James Canc Hosp, Columbus, OH 43210 USAFehniger, TA论文数: 0 引用数: 0 h-index: 0机构: Ohio State Univ, James Canc Hosp, Columbus, OH 43210 USAFuchs, A论文数: 0 引用数: 0 h-index: 0机构: Ohio State Univ, James Canc Hosp, Columbus, OH 43210 USAColonna, M论文数: 0 引用数: 0 h-index: 0机构: Ohio State Univ, James Canc Hosp, Columbus, OH 43210 USACaligiuri, MA论文数: 0 引用数: 0 h-index: 0机构: Ohio State Univ, James Canc Hosp, Columbus, OH 43210 USA