ReVolt:: Radiation-enhanced viral oncolytic therapy

被引：38

作者：

Advani, Sunil J.

Mezhir, James J.

Roizman, Bernard

Weichselbaum, Ralph R.

机构：

[1] Univ Chicago, Ctr Adv Med, Dept Surg, Chicago, IL 60637 USA

[2] Univ Chicago, Ctr Adv Med, Majorie B Kovler Viral Oncol Labs, Chicago, IL 60637 USA

[3] Univ Chicago, Ctr Adv Med, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2006年 / 66卷 / 03期

关键词：

ionizing radiation; viral oncolysis; radiation enhanced viral replication; cancer;

D O I：

10.1016/j.ijrobp.2006.06.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials. (c) 2006 Elsevier Inc.

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收藏

页码：637 / 646

页数：10

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