Erythropoietin is present in the cerebrospinal fluid of neonates

被引：56

作者：

Juul, SE

Harcum, J

Li, Y

Christensen, RD

机构：

[1] Division of Neonatology, Univ. of Florida College of Medicine, J. Hillis Miller Health Center, Gainesville, FL 32610-0296

来源：

JOURNAL OF PEDIATRICS | 1997年 / 130卷 / 03期

关键词：

D O I：

10.1016/S0022-3476(97)70205-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Erythropoietin (Epo) was measured by enzyme-linked immunosorbent assay in 80 cerebrospinal fluid (CSF) samples to determine whether Epo is present in the CSF of infants, CSF Epo concentrations correlate with age, and CSF Epo concentrations correlate with Epo therapy, Epo was present in the CSF of normal neonates, CSF Epo concentrations correlated negatively with increasing age, Recombinant Epo therapy did not affect CSF Epo concentrations, although values ranged somewhat higher in this group.

引用

页码：428 / 430

页数：3

共 12 条

[1] ERYTHROPOIETIN RECEPTOR MESSENGER-RNA EXPRESSION IN HUMAN ENDOTHELIAL-CELLS [J].

ANAGNOSTOU, A ;

LIU, ZY ;

STEINER, M ;

CHIN, K ;

LEE, ES ;

KESSIMIAN, N ;

NOGUCHI, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3974-3978

[2]

Juul Sandra E., 1996, Pediatric Research, V39, p219A

[3] TROPHIC EFFECT OF ERYTHROPOIETIN AND OTHER HEMATOPOIETIC FACTORS ON CENTRAL CHOLINERGIC NEURONS INVITRO AND INVIVO [J].

KONISHI, Y ;

CHUI, DH ;

HIROSE, H ;

KUNISHITA, T ;

TABIRA, T .

BRAIN RESEARCH, 1993, 609 (1-2) :29-35

[4] Erythropoietin receptors are expressed in the central nervous system of mid-trimester human fetuses [J].

Li, Y ;

Juul, SE ;

MorrisWiman, JA ;

Calhoun, DA ;

Christensen, RD .

PEDIATRIC RESEARCH, 1996, 40 (03) :376-380

[5] TISSUE-SPECIFIC EXPRESSION OF HUMAN ERYTHROPOIETIN RECEPTOR IN TRANSGENIC MICE [J].

LIU, ZY ;

CHIN, K ;

NOGUCHI, CT .

DEVELOPMENTAL BIOLOGY, 1994, 166 (01) :159-169

[6]

MASUDA S, 1994, J BIOL CHEM, V269, P19488

[7] Pharmacokinetics and effectiveness of recombinant erythropoietin administered to preterm infants by continuous infusion in total parenteral nutrition solution [J].

Ohls, RK ;

Veerman, MW ;

Christensen, RD .

JOURNAL OF PEDIATRICS, 1996, 128 (04) :518-523

[8]

SAWYER ST, 1989, BLOOD, V74, P103

[9]

SHANNON KM, 1995, PEDIATRICS, V95, P1

[10] FEEDBACK MODULATION OF RENAL AND HEPATIC ERYTHROPOIETIN MESSENGER-RNA IN RESPONSE TO GRADED ANEMIA AND HYPOXIA [J].

TAN, CC ;

ECKARDT, KU ;

FIRTH, JD ;

RATCLIFFE, PJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (03) :F474-F481

← 1 2 →