Novel synthetic analogs of the Pseudomonas autoinducer

被引：73

作者：

Kline, T ^{[1
]}

Bowman, J

Iglewski, BH

de Kievit, T

Kakai, Y

Passador, L

机构：

[1] PathoGenesis Corp, Seattle, WA 98119 USA

[2] Univ Rochester, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(99)00626-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-I and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-I and evaluated them in P. aeruginosa, Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ reporter construct. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3447 / 3452

页数：6

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