Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids

被引：85

作者：

Chevillet, John R. ^{[1
]}

Lee, Inyoul ^{[1
]}

Briggs, Hilary A. ^{[3
]}

He, Yuqing ^{[2
]}

Wang, Kai ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98109 USA

[2] Guangdong Med Coll, Inst Med Syst Biol, Dongguan 523808, Guangdong, Peoples R China

[3] Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA

来源：

MOLECULES | 2014年 / 19卷 / 05期

基金：

美国国家科学基金会;

关键词：

diagnostic; exosomes; microvesicles; quantitative methods; DROPLET-DIGITAL PCR; ACUTE MYOCARDIAL-INFARCTION; SMALL NONCODING RNAS; CIRCULATING MICRORNAS; ALZHEIMERS-DISEASE; MESSENGER-RNA; POTENTIAL BIOMARKERS; GENE-EXPRESSION; NUCLEIC-ACIDS; PLASMA;

D O I：

10.3390/molecules19056080

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities.

引用

页码：6080 / 6105

页数：26

共 190 条

[1] Plasma MicroRNA 499 as a Biomarker of Acute Myocardial Infarction [J].

Adachi, Taichi ;

Nakanishi, Michio ;

Otsuka, Yoritaka ;

Nishimura, Kunihiro ;

Hirokawa, Gou ;

Goto, Yoichi ;

Nonogi, Hiroshi ;

Iwai, Naoharu .

CLINICAL CHEMISTRY, 2010, 56 (07) :1183-1185

[2] Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction [J].

Ai, Jing ;

Zhang, Rong ;

Li, Yue ;

Pu, Jielin ;

Lu, Yanjie ;

Jiao, Jundong ;

Li, Kang ;

Yu, Bo ;

Li, Zhuqin ;

Wang, Rongrong ;

Wang, Lihong ;

Li, Qiang ;

Wang, Nina ;

Shan, Hongli ;

Li, Zhongyu ;

Yang, Baofeng .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (01) :73-77

[3] Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries [J].

Aird, Daniel ;

Ross, Michael G. ;

Chen, Wei-Sheng ;

Danielsson, Maxwell ;

Fennell, Timothy ;

Russ, Carsten ;

Jaffe, David B. ;

Nusbaum, Chad ;

Gnirke, Andreas .

GENOME BIOLOGY, 2011, 12 (02)

[4] MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function [J].

Albinsson, Sebastian ;

Suarez, Yajaira ;

Skoura, Athanasia ;

Offermanns, Stefan ;

Miano, Joseph M. ;

Sessa, William C. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (06) :1118-U80

[5]

Alexandrov Peter N, 2012, Int J Biochem Mol Biol, V3, P365

[6] A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus [J].

Alter, Harvey J. ;

Mikovits, Judy A. ;

Switzer, William M. ;

Ruscetti, Francis W. ;

Lo, Shyh-Ching ;

Klimas, Nancy ;

Komaroff, Anthony L. ;

Montoya, Jose G. ;

Bateman, Lucinda ;

Levine, Susan ;

Peterson, Daniel ;

Levin, Bruce ;

Hanson, Maureen R. ;

Genfi, Afia ;

Bhat, Meera ;

Zheng, HaoQiang ;

Wang, Richard ;

Li, Bingjie ;

Hung, Guo-Chiuan ;

Lee, Li Ling ;

Sameroff, Stephen ;

Heneine, Walid ;

Coffin, John ;

Hornig, Mady ;

Lipkin, W. Ian .

MBIO, 2012, 3 (05)

[7] A uniform system for microRNA annotation [J].

Ambros, V ;

Bartel, B ;

Bartel, DP ;

Burge, CB ;

Carrington, JC ;

Chen, XM ;

Dreyfuss, G ;

Eddy, SR ;

Griffiths-Jones, S ;

Marshall, M ;

Matzke, M ;

Ruvkun, G ;

Tuschl, T .

RNA, 2003, 9 (03) :277-279

[8] microRNAs: Tiny regulators with great potential [J].

Ambros, V .

CELL, 2001, 107 (07) :823-826

[9] Improved microRNA quantification in total RNA from clinical samples [J].

Andreasen, Ditte ;

Fog, Jacob U. ;

Biggs, William ;

Salomon, Jesper ;

Dahslveen, Ina K. ;

Baker, Adam ;

Mouritzen, Peter .

METHODS, 2010, 50 (04) :S6-S9

[10] K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer [J].

Anker, P ;

Lefort, F ;

Vasioukhin, V ;

Lyautey, J ;

Lederrey, C ;

Chen, XQ ;

Stroun, M ;

Mulcahy, HE ;

Farthing, MJG .

GASTROENTEROLOGY, 1997, 112 (04) :1114-1120

← 1 2 3 4 5 6 7 8 9 10 →